Florfenicol gaw amide hpan hta lawm ai, n-gun kaba ai-n-gun ja ai tsi langai mi re. Gram-positive hte Gram{3}}negative bacteria amyu myu hpe n-gun ja ai hku gasat dang la lu ai bacteria hpe pat shingdang lu ai bacteria langai mi rai nga ai. Hkum hkrang hta n-gun n rawng ai ana zinli ni gaw florfenicol hpe grai hkam sha chye ai. In vitro hta, florfenicol a n-gun n-gun gaw, n-gun n-gun law law hpe ninghkap lu ai atsam gaw, thiamphenicol hte bung ai (sh) grau n-gun ja ai. Acetylation a majaw amide-alcohol ni hpe ninghkap lu ai bacteria nkau mi, Escherichia coli hte Klebsiella pneumoniae zawn re ai ni gaw, florfenicol hpe naw hkam sha lu ai rai na re. Madung hku nna, gwi, gwi, nga ni hta byin pru wa ai bacteria ana zinli ni a matu jai lang ai, shing nrai, dumsu hte wa ni hta byin pru wa ai nsa sa lam ana zinli ni zawn re ai, sai chyup ana zinli ni a majaw byin pru wa ai bacteria ana zinli ni a matu lang ai. Salmonella, u hkum hkrang n-gun yawm ai, pullorum ana, Escherichia coli ana zinli ni a majaw byin pru wa ai shinggyim hkum hkrang n-gun yawm ai hte paratyphoid ana zinli ni hpe mung tsi lajang ya ai; hte nga ni hta byin pru wa ai bacteria septicemia, enteritis, red spot ana ni hpe mung mu lu ai. Pharmacokinetics: Florfenicol hpe n-gup hku lawan ladan hkam la lu nna, hkying hkum 1 daram hta sai hta tsi lajang ai n-gun de du wa nna, hkying hkum 1-3 laman hta plasma n-gun grau law ai de du wa ai. Bioavailability gaw 80% jan ai. Florfenicol gaw dusat hkum hkrang hta grai law hkra garan nga ai rai nna, sai-hkum hkrang shingnip hpe lai di lu ai. Madung hku nna n galai shai ai sha hka hta pru wa nna, loi mi sha hka hta pru wa ai.
Tsi hte seng ai lam
(1)Macrolides hte lincosamides ni gaw ndai tsi hte maren sha yaw shada ai lam nga ai, dai gaw bacteria ribosomes a 50S subunit hpe shingdaw na matu re. Shanhte hpe rau lang yang, n ju n dawng ai lam ni hpe shabyin ya lu ai.
(2)Penicillin (sh) aminoglycoside tsi ni a bacteria sat ai atsam hpe ninghkap lu ai, raitim ndai lam hpe dusat ni hta sakse n mu lu ai.
Tsi mawan hte hkam la ai lam
Ndai product hpe madung tawn nna. Kata na lang na matu: gwi hte gwi ni a hkum hkrang n-gun kg mi hta 0.1-0.15g, lani mi hta lahkawng lang 3-5 ya tup; Nga a matu hkum hkrang n-gun kg mi hta 50-75mg, lani mi hta kalang 3-5 ya tup jaw ra ai.
Sadi maja ra ai lam ni:
(1) Shinggyim masha ni sha na matu hkaulan mam hkai ai gwi ni gaw hkaulan mam-hkai ai aten hta ndai tsi hpe n mai lang ai.
(2) U ni hpe rem ai shaloi sadi maja let lang na. Shi hta embryo hpe hkra machyi shangun ai; na-um nasin hte chyu jaw nga ai dusat ni hpe sadi maja let lang ra ai.
(3) Katsi majan tsi htu ai aten (sh) hkum hkrang hkamja lam grai hkra machyi ai dusat ni hta n mai lang ai.
(4) Renal n-gun n rawng ai dusat ni hpe shanhte a tsi mawan hpe htap htuk ai hku shayawm ya ra ai (sh) tsi mawan jaw ai aten hpe jat ya ra ai.
Hot Tags: florfenicole n-gu, Miwa mung florfenicole n-gu galaw shapraw ai ni, jakrung
